Oxidative cross-coupling

Aromatic and heterocyclic aryl amines are important target molecules in organic synthesis due to their potential applications as pharmaceuticals and materials.

As a complement to the palladium-catalyzed amination procedure we established an oxidative cross-coupling reaction leading to primary, secondary or tertiary aryl amines.

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In addition, we extended the oxidative cross-coupling protocol to the preparation of polyfunctional alkynes via the formation of a C(sp²) - C(sp) bond.

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The functionalized benzofuran derivative is well suited for the preparation of new annulated pyridines.

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